This learning brief highlights how the Rural Entrepreneur Access Project (REAP)—piloted over a 2-year period in Napak District of Karamoja, Uganda—increased household incomes, food consumption levels, savings, and women’s agency in household decision-making and ownership and control of assets. The findings, conclusions, and lessons learned from this pilot can help a range of practitioners, including local government representatives, civil society organizations, policy makers, and donors engaged in the planning and allocation of resources for sustainable food and nutrition security among ultra-poor populations